The story begins when a wealthy industrialist named Mr. Jaguar learns about the existence of a legendary substance called Bio-Fluid. Desiring to exploit its potential for profit, Mr. Jaguar hires the famous scientist Dr. Collie to create a powerful bio-warrior using the Bio-Fluid. Dr. Collie succeeds in his experiment and creates Bio-Broly, a clone of the late Saiyan villain, Broly.
Meanwhile, Goku and his friends, including Vegeta, Trunks, and Krillin, are invited to a luxurious island to participate in a tournament hosted by Mr. Jaguar. Upon arrival, they discover that the tournament is a ruse orchestrated by Mr. Jaguar to lure them into a trap. Mr. Jaguar reveals his plan to use Bio-Broly as a weapon against Goku and his allies.
During the chaos that ensues, it is revealed that Bio-Broly is unstable and begins to liquefy, turning into a mindless blob. Goku and the others are forced to confront this monstrous creature, but even their combined powers struggle to defeat it. In desperation, they seek the help of Android 18, who possesses the ability to manipulate energy and might hold the key to stopping Bio-Broly.
With Android 18’s assistance, Goku and his friends devise a plan to freeze and shatter Bio-Broly, hoping to neutralize the threat. However, this plan is met with challenges as Bio-Broly continuously regenerates and evolves, becoming an even more formidable adversary. As the battle intensifies, the heroes must push their limits and find new ways to defeat the monstrous bio-warrior.